Truncated Prorenin Comes Up … Short

Commentary Truncated Prorenin Comes Up . . . Short

In the present issue of Hypertension, Xu et al1 report on a pivotal set of experiments that test the contribution of a key component to the action of the putative “intracellular reninangiotensin system” (RAS; iRAS) in its normal physiological setting. In contrast to the classic circulating RAS, the iRAS has been proposed to be wholly contained within cells, where it produces angiotensin peptide...

ICRP comes up trumps.

Human prorenin.

Human prorenin is the enzymatically inactive biosynthetic precursor of renin. Recent interest has focused on the posttranslational sorting and processing of prorenin to renin since markedly increased levels of circulating prorenin have been associated with both physiological and pathological changes. These observations raise the question of whether prorenin processing may be a regulatory event ...

Animal Memory: Chimpanzees Anticipate What Comes Next in Short Movies

A recent study shows that chimpanzees remember a movie they viewed one day earlier, and their eye movements show that they anticipate certain actions in that movie before those actions occur by looking to parts of the scene that are about to become relevant to the storyline.

An alternative transcript of the rat renin gene can result in a truncated prorenin that is transported into adrenal mitochondria.

Characterization of the local renin-angiotensin system in the rat adrenal zona glomerulosa indicated a dual targeting of renin both to the secretory pathway and mitochondria. To investigate the transport of renin into mitochondria, we constructed a series of amino-terminal deletion variants of preprorenin. One of these variants, lacking the complete signal sequence for the endoplasmic reticulum...